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  • 1

    Reading Guide

  • 2

    Introduction

  • 3

    Methods and processes

  • 4

    Consumer-centred care in the context of COVID-19

  • 5

    Definition of disease severity

    ▾
    • Definition of disease severity for adults

    • Definition of disease severity for children and adolescents
  • 6 Monitoring and markers of clinical deterioration
    ▾
    • Monitoring and markers of clinical deterioration
    • Pulse oximeters

      ▾
      • Pulse oximeters for adults

      • Pulse oximeters for children and adolescents

  • 7

    Drug treatments

    ▾
    • Recommended drug treatments

      ▾
      • Casirivimab plus imdevimab (Ronapreve)

        ▾
        • Casirivimab plus imdevimab (Ronapreve) for adults

        • Casirivimab plus imdevimab (Ronapreve) for pregnant or breastfeeding women

        • Casirivimab plus imdevimab (Ronapreve) for children and adolescents

      • Corticosteroids (inhaled)

        ▾
        • Corticosteroids (inhaled) for adults

        • Corticosteroids (inhaled) for children and adolescents

      • Corticosteroids (systemic)

        ▾
        • Corticosteroids (systemic) for adults

        • Corticosteroids (systemic) for pregnant or breastfeeding women

        • Corticosteroids (systemic) for children and adolescents

      • Molnupiravir (Lagevrio)

        ▾
        • Molnupiravir (Lagevrio) for adults

        • Molnupiravir (Lagevrio) for pregnant or breastfeeding women

        • Molnupiravir (Lagevrio) for children and adolescents

      • Nirmatrelvir plus ritonavir (Paxlovid)

        ▾
        • Nirmatrelvir plus ritonavir (Paxlovid) for adults

        • Nirmatrelvir plus ritonavir (Paxlovid) for pregnant or breastfeeding women

        • Nirmatrelvir plus ritonavir (Paxlovid) for children and adolescents

      • Other immunomodulating drugs
        ▾
        • Abatacept

          ▾
          • Abatacept for adults

        • Baricitinib
          ▾
          • Baricitinib for adults
          • Baricitinib for pregnant or breastfeeding women
          • Baricitinib for children and adolescents

        • Infliximab

          ▾
          • Infliximab for adults

        • Sarilumab
          ▾
          • Sarilumab for adults

          • Sarilumab for pregnant or breastfeeding women
          • Sarilumab for children and adolescents

        • Tocilizumab
          ▾
          • Tocilizumab for adults
          • Tocilizumab for pregnant or breastfeeding women
          • Tocilizumab for children and adolescents

      • Regdanvimab (Regkirona)

        ▾
        • Regdanvimab (Regkirona) for adults

        • Regdanvimab (Regkirona) for pregnant or breastfeeding women

        • Regdanvimab (Regkirona) for children and adolescents

      • Remdesivir (Veklury)

        ▾
        • Remdesivir (Veklury) for adults

        • Remdesivir (Veklury) for pregnant or breastfeeding women

        • Remdesivir (Veklury) for children and adolescents

      • Sotrovimab (Xevudy)

        ▾
        • Sotrovimab (Xevudy) for adults

        • Sotrovimab (Xevudy) for pregnant women

        • Sotrovimab (Xevudy) for children and adolescents

      • Tixagevimab plus cilgavimab (Evusheld)

        ▾
        • Tixagevimab plus cilgavimab (Evusheld) for adults

        • Tixagevimab plus cilgavimab (Evusheld) for pregnant or breastfeeding women

        • Tixagevimab plus cilgavimab (Evusheld) for children and adolescents

    • Drug treatments that are not recommended

      ▾
      • Aspirin
      • Azithromycin
      • Colchicine
      • Convalescent plasma
      • Favipiravir

      • Hydroxychloroquine
      • Hydroxychloroquine plus azithromycin
      • Interferon beta-1a

      • Interferon beta-1a plus lopinavir-ritonavir

      • Ivermectin

      • Lopinavir-ritonavir

    • Drug treatments not recommended outside of clinical trials

      ▾
      • Other drug treatments

    • Drug treatments under review

    • Drug treatments not currently under review

  • 8 Chemoprophylaxis
    ▾
    • Casirivimab plus imdevimab (Ronapreve) for post-exposure prophylaxis

    • Hydroxychloroquine for pre-exposure prophylaxis
    • Hydroxychloroquine for post-exposure prophylaxis
    • Tixagevimab plus cilgavimab (Evusheld) for pre-exposure prophylaxis

    • Tixagevimab plus cilgavimab (Evusheld) for post-exposure prophylaxis

  • 9 Respiratory support in adults
    ▾
    • Respiratory management

    • Respiratory management of the deteriorating patient

    • Videolaryngoscopy
    • Neuromuscular blockers
    • Positive end-expiratory pressure
    • Prone positioning
      ▾
      • Prone positioning for adults

      • Prone positioning for pregnant and postpartum women
      • Prone positioning and CPR

    • Recruitment manoeuvres
    • Extracorporeal membrane oxygenation
      ▾
      • ECMO for adults
      • ECMO for pregnant and postpartum women
  • 10 Respiratory support in neonates, children and adolescents
    ▾
    • Requiring non-invasive respiratory support
      ▾
      • High-flow nasal oxygen and non-invasive ventilation
      • Prone positioning (non-invasive)
      • Respiratory management of the deteriorating child
    • Requiring invasive mechanical ventilation
      ▾
      • Prone positioning (mechanical ventilation)
      • Positive end-expiratory pressure (PEEP)
      • Recruitment manoeuvres
      • Neuromuscular blockers
      • High-frequency oscillatory ventilation (HFOV)
      • Videolaryngoscopy
      • Extracorporeal membrane oxygenation (ECMO)
  • 11 Venous thromboembolism (VTE) prophylaxis
    ▾
    • VTE prophylaxis for adults
    • VTE prophylaxis for pregnant and postpartum women

    • VTE prophylaxis for children and adolescents

  • 12

    Therapies for existing indications in patients with COVID-19

    ▾
    • ACEIs/ARBs in patients with COVID-19
    • ACEIs in postpartum women
    • Steroids for people with asthma or COPD with COVID-19
    • Oestrogen-containing therapies

  • 13

    Care after COVID-19

    ▾
    • Goals of care

    • Assessment and diagnosis in patients with continuing symptoms after COVID-19

    • Management in patients with continuing symptoms after COVID-19

  • 14

    Timing of surgery following COVID-19 infection

  • 15 Pregnancy and perinatal care
    ▾
    • Antenatal corticosteroids

    • Magnesium sulfate

    • Mode of birth
    • Delayed umbilical cord clamping
    • Skin-to-skin contact
    • Breastfeeding
    • Rooming-in
  • 16 Child and adolescent care
    ▾
    • Paediatric Inflammatory Multisystem Syndrome (PIMS-TS)

      ▾
      • Aspirin and antithrombotic agents
      • Immunomodulatory agents

      • VTE prophylaxis

  • 17

    Abbreviations and Acronyms

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